Lucius Companions Portfolio Firm Voltron Therapeutics, Inc. Pronounces Completion of a Trial Protocol to Examine its Self Assembling Vaccine to Goal Prostate Stem Cell Antigen

Lucius Companions Portfolio Firm Voltron Therapeutics, Inc. Pronounces Completion of a Trial Protocol to Examine its Self Assembling Vaccine to Goal Prostate Stem Cell Antigen
  • Vaccine was proven to induce immunity in opposition to Prostate Stem Cell Antigen (PSCA) beforehand
  • Full protein focusing on expands the Self-Assembling Vaccine (SAV) platform’s potential targets

NEW YORK, Nov. 20, 2023 /PRNewswire/ — Voltron Therapeutics, Inc., a Lucius Companions portfolio firm, in the present day introduced that it has finalized the protocol for a Dose-Ranging Efficacy Examine of VTX-0P4, a protein-based most cancers vaccine focusing on Prostate Stem Cell Antigen (PSCA). PSCA is a key goal within the remedy of Prostate Most cancers. The flexibility of the SAV to focus on full proteins, in addition to peptides, demonstrates that Voltron’s vaccine platform has the potential to focus on dozens of oncology and infectious illness targets – collectively multi- billions of {dollars} of market potential. The pre-clinical trial is anticipated to start in December.

Voltron just lately demonstrated immunogenicity in opposition to PSCA in a double blind pre-clinical trial carried out on the Vaccine and Immunotherapy Heart on the Massachusetts Basic Hospital. In that trial VTX-0P4 considerably augmented T-Cell responses when in comparison with controls in opposition to this necessary tumor goal whereas, as soon as once more, exhibiting a really clear security profile. The magnitude of those responses had been similar to these seen within the Firm’s prior HPV E6/E7 research, which subsequently translated into important will increase in survival and reductions in tumor development in a mouse mannequin of HPV induced most cancers. This strongly suggests VTX-0P4 can handle PSCA or different tumor antigen expressing cancers with a full protein strategy.

Pat GallagherVoltron’s Chief Govt Officer commented, “In our HPV-related most cancers proof of idea trial, Voltron validated that focusing on sizzling spot epitopes, E6/E7, can result in extremely statistically important will increase in survival, diminished tumor progress, and elevated tumor infiltration by helpful immune T Cells. By utilizing a full protein in our PSCA trial to assault strong tumors of curiosity, we’re systematically shifting into extra complicated focusing on approaches that present elevated flexibility in creating therapies for extra most cancers varieties and infectious illnesses. As with our HPV design, this trial can even consider the particular vaccine as monotherapy and together with a Checkpoint Inhibitor (PD-1).”

The SAV Platform’s novel mechanism of motion affords a promising answer for fast improvement and manufacturing of vaccines at a diminished value. It makes use of the identical spine for all vaccines, however with completely different ‘focusing on warheads,’ permitting cost-effective manufacturing for particular most cancers or infectious illness targets. With the SAV, ‘focusing on warheads’ might probably embrace various kinds of antigens together with proteins, peptides, polysaccharides or nucleic acids. Importantly, using the identical core immune activating part throughout all of the vaccines, MTBHSP70, reduces regulatory dangers by largely eliminating off-target irritation inherent in customary adjuvants. Moreover, this makes use of an expression system Voltron has already translated to good manufacturing processes manufacturing for scientific testing.

“We’re excited to provoke Voltron’s PSCA pre-clinical efficacy trial,” mentioned James AhernManaging Accomplice of Laidlaw & Firm and co-founder of Lucius Companions. “With success, we can have two immune-oncology vaccines that probably handle six distinctive cancers to maneuver towards first-in-human trials. We are going to proceed to construct on our profitable applications to deal with affected person wants and create shareholder worth.”

About Voltron Therapeutics, Inc.

Voltron Therapeutics, Inc., a Delaware company, was based in 2017 to steer and speed up the event of the Vaccine and Immunotherapy Heart (VIC), and the Massachusetts Basic Hospital’s novel Self Assembling Vaccine know-how in a wide range of indications, together with in Oncology and Rising Infectious Illnesses. Voltron holds an unique worldwide license to this know-how.

With the work of our world class crew of researchers and improvement crew, this know-how has proven optimistic ends in sure pre-clinical research and preliminary proof of idea in two infectious illnesses (together with Lassa Fever) in addition to three oncology indications (HPV Associated Cancers). For extra data, please go to www.voltrontx.com.

About Lucius Companions, LLC

Lucius Companions is a consultancy that gives a broad suite of providers to assist healthcare firms develop, obtain milestones and generate worth for his or her shareholders.

Ahead Trying Statements

This press launch consists of “forward-looking statements” throughout the which means of the Personal Securities Litigation Reform Act of 1995. Ahead-looking statements on this press launch embrace, however usually are not restricted to, statements that relate to the development and improvement of the VaxCelerate Platform, the graduation of scientific trials, the provision of knowledge from scientific trials and different data that’s not historic data. When used herein, phrases resembling “anticipate”, “being”, “will”, “plan”, “might”, “proceed”, and related expressions are supposed to determine forward-looking statements. As well as, any statements or data that seek advice from expectations, beliefs, plans, projections, goals, efficiency or different characterizations of future occasions or circumstances, together with any underlying assumptions, are forward-looking. All forward-looking statements are primarily based upon Voltron’s present expectations and varied assumptions. Voltron believes there’s a cheap foundation for its expectations and beliefs, however they’re inherently unsure. Voltron might not notice its expectations, and its beliefs might not show appropriate. Precise outcomes might differ materially from these described or implied by such forward-looking statements on account of varied necessary elements, together with, with out limitation, market circumstances and any Voltron filings made with the Securities and Trade Fee. Consequently, forward-looking statements ought to be regarded solely as Voltron’s present plans, estimates and beliefs. Buyers shouldn’t place undue reliance on forward-looking statements. Voltron can not assure future outcomes, occasions, ranges of exercise, efficiency or achievements. Voltron doesn’t undertake and particularly declines any obligation to replace, republish, or revise any forward-looking statements to mirror new data, future occasions or circumstances or to mirror the occurrences of unanticipated occasions, besides as could also be required by legislation.

Contact:

Chris Bastardi (electronic mail protected) 917-484-1587
Julie Roginsky (electronic mail protected)

SOURCE Lucius Companions

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